4-tert-Butylcyclohexylmethanol → Cyclohexanecarboxaldehyde, 4-(1,1-dimethylethyl)-

HRID 653970

반응식

HRID 653970 반응식
[CH3:1][C:2]([CH:5]1[CH2:10][CH2:9][CH:8]([CH2:11][OH:12])[CH2:7][CH2:6]1)([CH3:4])[CH3:3].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[CH3:4][C:2]([CH:5]1[CH2:6][CH2:7][CH:8]([CH:11]=[O:12])[CH2:9][CH2:10]1)([CH3:1])[CH3:3]

참가 물질

4

반응물 2

HCID 827594-tert-ButylcyclohexylmethanolHCID 178418287HCID 178418287, 화합물

생성물 1

HCID 88655Cyclohexanecarboxaldehyde, 4-(1,1-dimethylethyl)-수율 87%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-(1,1-dimethylethyl)cyclohexanemethanol (1.0 g, 5.9 mmol) in CH2Cl2 (distilled from CaH2) (43 mL) were added at room temperature under argon anhydrous NaOAc (3.84 g, 46.8 mmol). After stirring at room temperature for 5 minutes pyridinium chlorochromate (3.84 g, 17.8 mmol) was added and after stirring for 1 h at room temperature, the reaction was quenched by addition of ethyl ether (200 mL). The crude reaction was filtered through a Fluorasil column to give crude 4-(1,1-dimethylethyl)cyclohexanecarboxaldehyde (0.862 g, 5.12 mmol) as a mixture of trans and cis isomer in 87% yield.

후처리

  1. additionwas added
  2. customthe reaction was quenched by addition of ethyl ether (200 mL)
  3. customThe crude reaction
  4. filtrationwas filtered through a Fluorasil column

출처 및 근거

ORD 기록
ord-021c9bf670ac429fbcb55df8c935b3f3
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05128448

연결된 노트

불러오는 중…