Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 4-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]-benzoic acid-[2-hydroxy-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethylamide]
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 4-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl)benzoic acid | HCID 3699990 | — |
| 반응물 | alpha-(Aminomethyl)-2,2-dimethyl-1,3-dioxolane-4-methanol | HCID 11971028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 4-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]-benzoic acid-[2-hydroxy-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethylamide] | HCID 67899351 | — |
반응 단계
Analogously to Example 11(a), 3.63 g (10 mmol) of 4-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl)benzoic acid in ethyl acetate with SOCl2 is converted into the acid chloride and the latter is reacted with 1.93 g (12 mmol) of 2-hydroxy-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethylamine and the crude product is purified by chromatography. 4.2 g=82.9% of the theoretical yield of the compound is obtained as an amorphous solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05130119 |
| 출처 데이터셋 | uspto-grants-1992_07 |
| ORD ID | ord-e4a9023e10de4979b628488c50ee5cfb |
| 출처 메모 | uspto-grants-1992_07 |