Triethylamine → 3-Phenyliminohexahydro-3H-oxazolo[3,4-a]pyridine

HRID 654400

반응식

HRID 654400 반응식
[CH:1]1[CH:6]=[CH:5][C:4]([N:7]=[C:8](Cl)Cl)=[CH:3][CH:2]=1.C(N(CC)CC)C.[OH:18][CH2:19][CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][NH:21]1>C(Cl)Cl>[C:4]1([N:7]=[C:8]2[N:21]3[CH2:22][CH2:23][CH2:24][CH2:25][CH:20]3[CH2:19][O:18]2)[CH:5]=[CH:6][CH:1]=[CH:2][CH:3]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 12145Phenylimidocarbonyl chlorideHCID 94263Piperidin-2-ylmethanol

생성물 1

HCID 144419173-Phenyliminohexahydro-3H-oxazolo[3,4-a]pyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

3 g Phenyl isocyanide dichloride in 10 ml methylene chloride was treated at room temperature with a solution of 5.4 ml triethylamine and 1.7 g 2-hydroxymethylpiperidine in 20 ml methylene chloride. After 12 hours at room temperature, the mixture was washed with water, the organic phase was dried over magnesium sulphate, the solvent was distilled and the residue recrystallised from diisopropyl ether.

후처리

  1. washthe mixture was washed with water
  2. dry with materialthe organic phase was dried over magnesium sulphate
  3. distillationthe solvent was distilled
  4. customthe residue recrystallised from diisopropyl ether

출처 및 근거

ORD 기록
ord-783c1be8ceb944d8b2390e4b3079cd9b
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05131946

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