4-Hydroxybenzaldehyde → 4-(2-Butoxyethoxy)benzaldehyde

HRID 654414노트

반응식

HRID 654414 반응식
Br[CH2:2][CH2:3][O:4][CH2:5][CH2:6][CH2:7][CH3:8].[OH:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=[O:15])=[CH:12][CH:11]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:5]([O:4][CH2:3][CH2:2][O:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=[O:15])=[CH:12][CH:11]=1)[CH2:6][CH2:7][CH3:8]

참가 물질

5

반응물 3

HCID 1264-HydroxybenzaldehydeHCID 11430Potassium CarbonateHCID 1387612-Butoxyethyl bromide

생성물 1

HCID 198872374-(2-Butoxyethoxy)benzaldehyde수율 64%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Nine grams (0.05 mole) of 1-bromo-2-butoxy-ethane and 6.1 grams (0.05 mole) of 4-hydroxybenzaldehyde were dissolved in 75 mls. of acetonitrile. Into the mixture were added 13.8 grams (0.1 mole) of finely ground potassium carbonate and the resulting reaction mixture was stirred under reflux for ten hours. The reaction mixture was allowed to cool, was filtered, washed with acetonitrile and evaporated to an amber oily product. The product was passed through a silica gel chromatographic column for recovery of a colorless oil (64% yield) having the following structure: ##STR20##

후처리

  1. customthe resulting reaction mixture
  2. temperatureunder reflux for ten hours
  3. temperatureto cool
  4. filtrationwas filtered
  5. washwashed with acetonitrile
  6. customevaporated to an amber oily product

출처 및 근거

ORD 기록
ord-713a336d939e408ebc21ec034e7fddc7
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05132041

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