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4-Toluenesulfonyl chloride → Z-1-(4-methylphenylsulfonyloxymethyl)-1-(4-fluorophenyl)-2-(3-cyclohexenyl)-ethene

HRID 654466
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HRID 654466 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[OH:12][CH2:13]/[C:14](/[C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)=[CH:15]\[CH:16]1[CH2:21][CH2:20][CH:19]=[CH:18][CH2:17]1>C(Cl)Cl.C(N(CC)CC)C>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O:12][CH2:13]/[C:14](/[C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)=[CH:15]\[CH:16]2[CH2:21][CH2:20][CH:19]=[CH:18][CH2:17]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1
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참가 물질

5

반응물 2

HCID 73974-Toluenesulfonyl chlorideHCID 19774242Z-1-hydroxymethyl-1-(4-fluorophenyl)-2-(3-cyclohexenyl)ethene

생성물 1

HCID 86745997Z-1-(4-methylphenylsulfonyloxymethyl)-1-(4-fluorophenyl)-2-(3-cyclohexenyl)-ethene수율 95%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8471Triethylamine용매

실험 절차

32.5 g of 4-methylbenzenesulfonyl chloride are added, at room temperature, to a solution of 34 g of Z-1-hydroxymethyl-1-(4-fluorophenyl)-2-(3-cyclohexenyl)ethene in 200 ml of methylene chloride and 29 g of triethylamine. After 24 hours, the reaction mixture is washed with aqueous sodium bicarbonate solution and water, dried over sodium sulfate and evaporated down under reduced pressure. 49.7 g (95%) of Z-1-(4-methylphenylsulfonyloxymethyl)-1-(4-fluorophenyl)-2-(3-cyclohexenyl)-ethene are obtained from the residue.

후처리

  1. washthe reaction mixture is washed with aqueous sodium bicarbonate solution and water
  2. dry with materialdried over sodium sulfate
  3. customevaporated down under reduced pressure

출처 및 근거

ORD 기록
ord-4085573286f244abb7721d6e0a5259af
출처 데이터셋
uspto-grants-1992_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05132318

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