Carbon Tetrachloride → Dimethyl alpha-chloro-alpha-methylmalonate

HRID 654603

반응식

HRID 654603 반응식
[CH3:1][CH:2]([C:7]([O:9][CH3:10])=[O:8])[C:3]([O:5][CH3:6])=[O:4].[Cl:11]C(Cl)(Cl)Cl>[F-].C([N+](CCCC)(CCCC)CCCC)CCC>[Cl:11][C:2]([CH3:1])([C:7]([O:9][CH3:10])=[O:8])[C:3]([O:5][CH3:6])=[O:4]

참가 물질

4

반응물 2

HCID 5943Carbon TetrachlorideHCID 69104Dimethyl methylmalonate

생성물 1

HCID 10943067Dimethyl alpha-chloro-alpha-methylmalonate수율 63.1%

시약·촉매·용매 1

HCID 2724141Tetrabutylammonium Fluoride촉매

실험 절차

In a 10 mL round-bottom flask, a mixture of 1.46 g dimethyl methylmalonate (10 mmol), 1.69 g tetrachloromethane (11 mmol), and 63 mg tetra-n-butylammonium fluoride (0.2 mmol) was mixed by a magnetic stirrer for 15 min at 24° C. Gas chromatographic analysis of the product mixture showed that the solution contained 1.14 g of dimethyl α-chloro-α-methylmalonate (63% yield).

후처리

  1. additionwas mixed by a magnetic stirrer for 15 min at 24° C

출처 및 근거

ORD 기록
ord-b04e98ad4b4442ffa79ccdf0dd51c413
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05132475

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