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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Diethyl ethylmalonate → Diethyl chloroethylmalonate

HRID 654607
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인쇄 미리보기

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HRID 654607 반응식
[CH2:1]([CH:3]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].[Cl:14]C(Cl)(Cl)C(OCC)=O>O.O.O.[F-].C([N+](CCCC)(CCCC)CCCC)CCC.C(=O)([O-])[O-].[K+].[K+]>[Cl:14][C:3]([CH2:1][CH3:2])([C:9]([O:11][CH2:12][CH3:13])=[O:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 8610Diethyl ethylmalonateHCID 10588Ethyl trichloroacetate

생성물 1

HCID 121803Diethyl chloroethylmalonate수율 70.1%

시약·촉매·용매 2

HCID 11430Potassium Carbonate촉매HCID 11726816Tetrabutylammonium Fluoride Trihydrate촉매

실험 절차

In a 10 mL round-bottom flask, 1.88 g of diethyl ethylmalonate (10 mmol), 2.10 g of ethyl trichloroacetate (11 mmol), 158 mg of tetra-n-butylammonium fluoride trihydrate (0.5 mmol), and 69 mg of potassium carbonate (0.5 mmol) were stirred at 24° C. for 5 h. After filtration, the solution was found to contain 1.56 g (70% yield) of diethyl α-chloro-α-ethylmalonate.

후처리

  1. filtrationAfter filtration

출처 및 근거

ORD 기록
ord-bf9b038c957d4ccf9eda320c0a3fec1a
출처 데이터셋
uspto-grants-1992_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05132475

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