Bromotrichloromethane → (Bromoethynyl)benzene

HRID 654608노트

반응식

HRID 654608 반응식
[C:1]1([C:7]#[CH:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:9]C(Cl)(Cl)Cl>O.O.O.[F-].C([N+](CCCC)(CCCC)CCCC)CCC.C1(C#C)C=CC=CC=1>[Br:9][C:8]#[C:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 2

HCID 6383BromotrichloromethaneHCID 10821Phenylacetylene

생성물 1

HCID 136737(Bromoethynyl)benzene수율 95%

시약·촉매·용매 2

HCID 10821Phenylacetylene촉매HCID 11726816Tetrabutylammonium Fluoride Trihydrate촉매

실험 절차

In a 10 mL round-bottom flask, 1.02 g of phenylacetylene (10 mmol), 2.1 g bromotrichloromethane (10.5 mmol) and 100 mg of tetra-n-butylammonium fluoride trihydrate (0.316 mmol) were stirred at 24° C. for 15 min. The temperature of the mixture rose to 33° C. in the course of the process. Analysis of the resulting mixture showed that it contained 1.72 g of 1-bromo-2-phenylacetylene (95% yield) and 0.05 g of the unconverted phenylacetylene.

후처리

  1. customrose to 33° C. in the course of the process

출처 및 근거

ORD 기록
ord-0484acd9f3944462977eedecda75db40
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05132475

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