Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromoform → Dimethyl 2-bromo-2-methylmalonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromoform | HCID 5558 | — |
| 반응물 | Carbon tetrabromide | HCID 11205 | — |
| 반응물 | Dimethyl methylmalonate | HCID 69104 | — |
| 촉매 | Tetrabutylammonium Fluoride Trihydrate | HCID 11726816 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Dimethyl 2-bromo-2-methylmalonate | HCID 12681741 | 87.5% |
반응 단계
A solution of 3.25 g tetrabromomethane (10 mmol), 1.46 g dimethyl methylmalonate (10 mmol), and 100 mg tetra-n-butylammonium fluoride trihydrate (0.316 mmol) in 5 mL tetrahydrofuran (THF) was stirred for 10 min at 24° C. Gas chromatographic analysis of the resulting mixture showed that it contained 87% yield of both dimethyl α-bromo-α-methylmalonate (1.97 g) and bromoform (2.2 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05132475 |
| 출처 데이터셋 | uspto-grants-1992_07 |
| ORD ID | ord-2a12a76e248e475dbe388e32650d1b85 |
| 출처 메모 | uspto-grants-1992_07 |