Sodium Cyanide → 3-Methoxy-5-methylthio-4-propoxyphenyl acetonitrile

HRID 654623노트

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HRID 654623 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([S:15][CH3:16])[C:10]=1[O:11][CH2:12][CH2:13][CH3:14])[CH2:6]Cl.[C-:17]#[N:18].[Na+]>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:6][C:17]#[N:18])[CH:8]=[C:9]([S:15][CH3:16])[C:10]=1[O:11][CH2:12][CH2:13][CH3:14]

참가 물질

4

반응물 2

HCID 8929Sodium CyanideHCID 15044966HCID 15044966, 화합물

생성물 1

HCID 150449673-Methoxy-5-methylthio-4-propoxyphenyl acetonitrile수율 95%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To 16 g of 3-methoxy-5-methylthio-4-propoxybenzyl chloride in 100 ml of dry DMF was added 5 g (0.10 mole) sodium cyanide. The mixture was stirred for about 48 hours at rom temperature under N2. The solution was filtered, and the filtrate was concentrated under vacuum. The residue was purified by flash column chromatography to yield 14.5 g of 3-methoxy-5-methylthio-4-propoxyphenyl acetonitrile as an oil. (95% yield).

후처리

  1. filtrationThe solution was filtered
  2. concentrationthe filtrate was concentrated under vacuum
  3. customThe residue was purified by flash column chromatography

출처 및 근거

ORD 기록
ord-020ee06462ca4e4fa68d3770a9198c20
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05132463

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