Benzene, (3-chloro-1-propenyl)- → 1-(Vinylbenzyl)-3-((S)-alpha-methylbenzylcarbamoyl)-pyridinium chloride

HRID 65471

반응식

HRID 65471 반응식
[CH3:1][C@H:2]([NH:9][C:10](=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[N:13][CH:12]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Cl:18][CH2:19][CH:20]=[CH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>CO>[Cl-:18].[CH:20]([CH:21]([N+:13]1[CH:14]=[CH:15][CH:16]=[C:11]([C:10](=[O:17])[NH:9][C@@H:2]([CH3:1])[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:12]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[CH2:19]

참가 물질

4

반응물 2

HCID 94242Benzene, (3-chloro-1-propenyl)-HCID 765754N-((S)-alpha-methylbenzyl)nicotinamide

생성물 1

HCID 704518671-(Vinylbenzyl)-3-((S)-alpha-methylbenzylcarbamoyl)-pyridinium chloride수율 89.8%

시약·촉매·용매 1

HCID 887Methanol용매2회

반응 조건

온도
25 °C

실험 절차

A 100 ml methanol solution containing 2.26 g (1.00×10-2 mols) of N-((S)-α-methylbenzyl)nicotinamide was charged into a 250 ml round bottom flask equipped with condenser, addition funnel, drying tube, nitrogen purge and magnetic stirrer. To this stirred reaction mixture was added, dropwise over a 10 minute interval, 50 ml of a methanol solution containing 1.53 g (1.00×10-2 mols) of chloromethylstyrene. The solution was stirred for 24 hours at 25° C., then was concentrated under vacuum to afford solid which was recrystallized from methanol to yield 3.40 g (8.98×10-3 mols) of product.

후처리

  1. additionwas charged into a 250 ml round bottom flask
  2. customequipped with condenser, addition funnel
  3. customdrying tube
  4. customnitrogen purge
  5. customTo this stirred reaction mixture
  6. concentrationwas concentrated under vacuum
  7. customto afford solid which
  8. customwas recrystallized from methanol

출처 및 근거

ORD 기록
ord-5f8417b8409e4cb6abf2aaa05ff224db
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04614770

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