Ammonia → HCID 85549673, 화합물
반응식
[F:1][CH:2]([C:8](=O)[C:9]([F:12])([F:11])[F:10])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[NH3:14]>C1(C)C=CC=CC=1>[NH2:14][C:8]([C:9]([F:12])([F:11])[F:10])=[C:2]([F:1])[C:3]([O:5][CH2:6][CH3:7])=[O:4]참가 물질
4
실험 절차
Ethyl 2,4,4,4-tetrafluoro-3-oxobutanoate (81 g.) in toluene (60 ml) was stirred and heated to 70° C. whereupon ammonia gas was bubbled in until an uptake of 6.8 g. was recorded. The reaction was then set for reflux and water removed azeotropically. Approximately 10 ml of water was removed. After cooling, the solvent was removed under reduced pressure and the residue distilled to give ethyl 3-amino-2,4,4,4-tetrafluoro-2-butenoate b.p. 79°-86° C./20 mm, 44 g.
후처리
- customwas bubbled in until an uptake of 6.8 g
- temperaturefor reflux
- customwater removed azeotropically
- customApproximately 10 ml of water was removed
- temperatureAfter cooling
- customthe solvent was removed under reduced pressure
- distillationthe residue distilled
출처 및 근거
- ORD 기록
- ord-1c52539500b645c182927bb0d6e9964f
- 출처 데이터셋
- uspto-grants-1992_07
- 특허 번호
- US05134145
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