4-Fluorophenylhydrazine hydrochloride → HCID 19886090, 화합물

HRID 654777노트

반응식

HRID 654777 반응식
[C:1]1([CH3:17])[CH:6]=[CH:5][C:4]([C:7](=O)[CH2:8][C:9](=O)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:3][CH:2]=1.Cl.[F:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][NH2:27])=[CH:22][CH:21]=1>O1CCOCC1.C(O)C>[F:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]2[C:7]([C:4]3[CH:5]=[CH:6][C:1]([CH3:17])=[CH:2][CH:3]=3)=[CH:8][C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[N:27]2)=[CH:22][CH:21]=1

참가 물질

5

반응물 2

HCID 699814-Fluorophenylhydrazine hydrochlorideHCID 595052Ethyl 2,4-dioxo-4-(p-tolyl)butanoate

생성물 1

HCID 19886090HCID 19886090, 화합물수율 41.5%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 312751,4-Dioxane용매

실험 절차

A mixture of ethyl 4-(4-tolyl)-2,4-dioxobutanoate (4.7 g) and 4-fluorophenylhydrazine hydrochloride (3.6 g) in dioxane (35 ml) and ethanol (35 ml) was refluxed for 5 hours. The mixture was filtered and the filtrate was concentrated in vacuo. The oily residue (8 g) was purified.by column chromatography on silica gel (130 g) eluting with chloroform to give an oil of ethyl 1-(4-fluorophenyl)-5-(4-tolyl)pyrazole-3-carboxylate (2.7 g).

후처리

  1. temperaturewas refluxed for 5 hours
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate was concentrated in vacuo
  4. washeluting with chloroform

출처 및 근거

ORD 기록
ord-e9c98eacbb4a4fa49693d26d9df75d47
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05134142

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