Bromomethyl 4-methoxyphenyl ketone → 2-(4-Methoxyphenyl)indolizine
반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH3:7].[CH3:8][O:9][C:10]1[CH:19]=[CH:18][C:13]([C:14](=O)[CH2:15]Br)=[CH:12][CH:11]=1>C(O)C.O>[CH3:8][O:9][C:10]1[CH:19]=[CH:18][C:13]([C:14]2[CH:7]=[C:2]3[N:1]([CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3]3)=[CH:12][CH:11]=1참가 물질
5
실험 절차
10 g of 2-picoline and 25 g of 4-methoxyphenacyl bromide in 35 ml of ethanol were refluxed for 18 hours. The reaction solution was concentrated under reduced pressure to give a solid, which was dissolved in 350 ml of water. After the aqueous solution was extracted with three 35 ml portions of ether, 35 g of sodium bicarbonate was added to the aqueous solution and was refluxed two hours. The cooled reaction mixture was filtered to give 20 g of product.
후처리
- concentrationThe reaction solution was concentrated under reduced pressure
- customto give a solid, which
- extractionAfter the aqueous solution was extracted with three 35 ml portions of ether, 35 g of sodium bicarbonate
- additionwas added to the aqueous solution
- temperaturewas refluxed two hours
- customThe cooled reaction mixture
- filtrationwas filtered
출처 및 근거
- ORD 기록
- ord-8c6c6592fb4c4d65849b97e47bb9822d
- 출처 데이터셋
- uspto-grants-1986_09
- 특허 번호
- US04614801
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