2,2-Dimethyltetrahydropyran-4-one → 4-(3-Benzyloxyphenyl)-4-hydroxy-2,2-dimethyltetrahydropyran

반응식

[CH2:1]([O:8][C:9]1[CH:10]=[C:11](Br)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:16][C:17]1([CH3:24])[CH2:22][C:21](=[O:23])[CH2:20][CH2:19][O:18]1>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:21]2([OH:23])[CH2:20][CH2:19][O:18][C:17]([CH3:24])([CH3:16])[CH2:22]2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 17381592,2-Dimethyltetrahydropyran-4-one

HCID 27566381-(Benzyloxy)-3-bromobenzene

생성물 1

HCID 200806534-(3-Benzyloxyphenyl)-4-hydroxy-2,2-dimethyltetrahydropyran수율 72%

실험 절차

Using the procedure described in the second paragraph of Note c. below Table I in Example 2, 3-benzyloxybromobenzene (1.34 g) was reacted with 2,2-dimethyltetrahydropyran-4-one (0.65 g) to give 4-(3-benzyloxyphenyl)-4-hydroxy-2,2-dimethyltetrahydropyran (1.14 g, 72%), as an oil.

출처 및 근거

ORD 기록: ord-e5e918fb29f34ad590d186498c1b185d
출처 데이터셋: uspto-grants-1992_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05134148

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