3,3,5-Trimethylcyclohexanol → 3,3,5-Trimethylcyclohexyl N-benzyloxycarbonyl-L-pyroglutamate

HRID 654835노트

반응식

HRID 654835 반응식
[CH2:1]([O:8][C:9]([N:11]1[C:15](=[O:16])[CH2:14][CH2:13][C@H:12]1[C:17]([OH:19])=[O:18])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CN(C1C=CC=CN=1)C.[CH3:29][C:30]1([CH3:38])[CH2:35][CH:34]([CH3:36])[CH2:33][CH:32](O)[CH2:31]1.C1(N=C=NC2CCCCC2)CCCCC1>CN(C)C=O>[CH2:1]([O:8][C:9]([N:11]1[C:15](=[O:16])[CH2:14][CH2:13][C@H:12]1[C:17]([O:19][CH:32]1[CH2:33][CH:34]([CH3:36])[CH2:35][C:30]([CH3:38])([CH3:29])[CH2:31]1)=[O:18])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 82983,3,5-TrimethylcyclohexanolHCID 10868DicyclohexylcarbodiimideHCID 218852-DimethylaminopyridineHCID 6376481-(Phenylmethyl) (2S)-5-oxo-1,2-pyrrolidinedicarboxylate

생성물 1

HCID 228451423,3,5-Trimethylcyclohexyl N-benzyloxycarbonyl-L-pyroglutamate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

34.2 g (0.13 mol) of N-benzyloxycarbonyl-L-pyroglutamic acid (prepared according to Berichte 97, 2434 [1964] or Annalen 649, 183 [1961] ) are added to 150 ml of dimethylformamide, followed by 2 g of dimethylaminopyridine and then 18.48 g (0.13 mol) of 3,3,5-trimethylcyclohexanol (mixture of 90% trans isomer and 10% cis isomer) diluted in 50 ml of dimethylformamide. 26.8 g (0.13 mol) of dicyclohexylcarbodiimide are then run in over a period of about 15 minutes, the reaction medium being kept at +5° C. The mixture is then stirred at room temperature for 24 hours, after which the solvent is evaporated off, the residue is taken up with dilute hydrochloric acid and extraction is carried out with chloroform.

후처리

  1. customare then run in over a period of about 15 minutes
  2. custombeing kept at +5° C
  3. customafter which the solvent is evaporated off
  4. extractionthe residue is taken up with dilute hydrochloric acid and extraction

출처 및 근거

ORD 기록
ord-66651c66750d4be383bc594105b77fa0
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05134157

반응 노트

불러오는 중…