5-(Pyridin-2-yl)pent-4-yn-1-ol → 2-Pyridinepentanol

HRID 654936노트

반응식

HRID 654936 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]#[C:8][CH2:9][CH2:10][CH2:11][OH:12]>C(OCC)C.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]

참가 물질

4

반응물 1

HCID 109973535-(Pyridin-2-yl)pent-4-yn-1-ol

생성물 1

HCID 143474782-Pyridinepentanol

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 3283Diethyl Ether용매

실험 절차

A solution of 5-(2-pyridyl)-4-pentyn-1-ol (1 g, 6.2 mmol) in diethyl ether (15 ml) was hydrogenated over 10% palladium on carbon at room temperature for 16 h. The mixture was filtered through celite and the filtrate on evaporation gave an oil, which was flash chromatographed on silica using 80% ethyl acetate/chloroform. Fractions with Rf of about 0.06 on evaporation gave the title alcohol as a yellow oil.

후처리

  1. filtrationThe mixture was filtered through celite
  2. customthe filtrate on evaporation
  3. customgave an oil, which
  4. customchromatographed on silica using 80% ethyl acetate/chloroform
  5. customFractions with Rf of about 0.06 on evaporation

출처 및 근거

ORD 기록
ord-8c36a7b54eb649aeb64e5b8168272bb1
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05134128

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