1,2-Dibromoethane → HCID 54310569, 화합물

HRID 654949노트

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HRID 654949 반응식
[O:1]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][Mg]Br)[Si:2]([C:5]([CH3:8])([CH3:7])[CH3:6])([CH3:4])[CH3:3].BrCCCCCCCCO[Si](C(C)(C)C)(C)C.[Mg].BrCCBr.[CH3:41][Si:42]([CH3:51])([CH3:50])[C:43]1[O:47][CH:46]=[C:45]([CH:48]=[O:49])[CH:44]=1>O1CCCC1>[OH:49][CH:48]([C:45]1[CH:44]=[C:43]([Si:42]([CH3:51])([CH3:50])[CH3:41])[O:47][CH:46]=1)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][O:1][Si:2]([C:5]([CH3:8])([CH3:7])[CH3:6])([CH3:4])[CH3:3]

참가 물질

7

반응물 5

HCID 78391,2-DibromoethaneHCID 5462224MagnesiumHCID 10969362Silane, [(8-bromooctyl)oxy](1,1-dimethylethyl)dimethyl-HCID 156632515-(Trimethylsilyl)furan-3-carbaldehydeHCID 178455211HCID 178455211, 화합물

생성물 1

HCID 54310569HCID 54310569, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a stirred solution of 8-t-butyldimethylsiloxyoctylmagnesium bromide (5.63 mmol prepared from 1-bromo-8-t-butyldimethylsiloxyoctane 1.82 g, 5.63 mmol and 6.19 mmol magnesium; with a catalytic amount of 1,2-dibromoethane as initiator) in tetrahydrofuran (2 ml) at 0° under argon was added dropwise 5-trimethylsilyl-3-furaldehyde (0.866 g, 5.15 mmol) in tetrahydrofuran (10 ml). The solution was warmed to room temperature, stirred for one hour, quenched with cold 10% hydrochloric acid and extracted into ethyl ether. The organic portion was washed with saturated sodium bicarbonate, water saturated sodium chloride solution, dried over magnesium sulfate, filtered and concentrated to give a pale oil. Purification by flash chromatography (silica, 5 to 10% ethyl acetate/hexane) gave the desired alcohol.

후처리

  1. customquenched with cold 10% hydrochloric acid
  2. extractionextracted into ethyl ether
  3. washThe organic portion was washed with saturated sodium bicarbonate, water saturated sodium chloride solution
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customto give a pale oil
  8. customPurification by flash chromatography (silica, 5 to 10% ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-7886fa1c1d4a47ed87b017fd930a3747
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05134128

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