4,4'-(2-Aminoethylidene)bisphenol → HCID 86645703, 화합물

HRID 655126

반응식

HRID 655126 반응식
[CH2:1]([N:8]1[N:12]=[N:11][C:10]([C@@H:13]2[C@@H:17]([OH:18])[C@@H:16]([OH:19])[C@H:15]([N:20]3[CH:28]=[N:27][C:26]4[C:21]3=[N:22][C:23]([Cl:44])=[N:24][C:25]=4NCC(C3C=CC=CC=3)C3C=CC=CC=3)[O:14]2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:45][CH2:46][CH:47]([C:55]1[CH:60]=[CH:59][C:58]([OH:61])=[CH:57][CH:56]=1)[C:48]1[CH:53]=[CH:52][C:51]([OH:54])=[CH:50][CH:49]=1>>[CH2:1]([N:8]1[N:12]=[N:11][C:10]([C@@H:13]2[C@@H:17]([OH:18])[C@@H:16]([OH:19])[C@H:15]([N:20]3[CH:28]=[N:27][C:26]4[C:21]3=[N:22][C:23]([Cl:44])=[N:24][C:25]=4[NH:45][CH2:46][CH:47]([C:48]3[CH:49]=[CH:50][C:51]([OH:54])=[CH:52][CH:53]=3)[C:55]3[CH:60]=[CH:59][C:58]([OH:61])=[CH:57][CH:56]=3)[O:14]2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 217102804,4'-(2-Aminoethylidene)bisphenol2회HCID 86645702HCID 86645702, 화합물

생성물 1

HCID 86645703HCID 86645703, 화합물

실험 절차

The title compound is prepared in an analogous fashion to (2R,3S,4R,5R)-2-(2-benzyl-2H-tetrazol-5-yl)-5-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-tetrahydro-furan-3,4-diol (WO 99/38877) by replacing 2,2-diphenylethylamine with 4,4′-(2-aminoethylidene)bis-phenol (Intermediate A).

출처 및 근거

ORD 기록
ord-d54b4eb33b0c4bd49354dd0216ad804c
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071565B2

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