3-(2-Pyridyl)-2-cyclopenten-1-one → 3-(2-Pyridyl)cyclopentan-1-one

HRID 655137노트

반응식

HRID 655137 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH2:11][CH2:10][C:9](=[O:12])[CH:8]=1>CCO.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]1[CH2:11][CH2:10][C:9](=[O:12])[CH2:8]1

참가 물질

4

반응물 1

HCID 392355473-(2-Pyridyl)-2-cyclopenten-1-one

생성물 1

HCID 594861153-(2-Pyridyl)cyclopentan-1-one수율 225.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 3-(2-pyridyl)-2-cyclopenten-1-one (1.43 g, 8.98 mmol) and 10% Pd/C (142 mg) in EtOH (30 mL) was stirred under hydrogen atmosphere (0.3 MPa) for 6.5 h. The catalyst was removed by filtration over Celite and the filtrate was concentrated in vacuo. The crude product was purified by column chromatography (Hexane/EtOAc=1/1) to yield 3-(2-pyridyl)cyclopentan-1-one (3.26 g, 94%) as colorless oil.

후처리

  1. customThe catalyst was removed by filtration over Celite
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe crude product was purified by column chromatography (Hexane/EtOAc=1/1)

출처 및 근거

ORD 기록
ord-68742832c65740f2be7f38b4ca104c31
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071591B2

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