trans-N-[3-(3-pyridyl)cyclohexyl]phthalimide → trans-3-(3-Pyridyl)cyclohexylamine

HRID 655171노트

반응식

HRID 655171 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C@H:7]2[CH2:12][CH2:11][CH2:10][C@H:9]([N:13]3C(=O)C4=CC=CC=C4C3=O)[CH2:8]2)[CH:2]=1>CCO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C@H:7]2[CH2:12][CH2:11][CH2:10][C@H:9]([NH2:13])[CH2:8]2)[CH:2]=1

참가 물질

3

반응물 1

HCID 67133459trans-N-[3-(3-pyridyl)cyclohexyl]phthalimide

생성물 1

HCID 67133702trans-3-(3-Pyridyl)cyclohexylamine수율 62.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of trans-N-[3-(3-pyridyl)cyclohexyl]phthalimide (3.00 g, 9.79 mmol) and hydrazinemonohydorate (0.95 mL, 19.6 mmol) in EtOH (40 mL) was stirred at room temperature for 1.5 h. The reaction mixture was filtered followed by the removal of solvent. The crude product was purified by column chromatography (NH, EtOAc) to yield trans-3-(3-pyridyl)cyclohexylamine (1.08 g, 60%) as colorless oil.

후처리

  1. filtrationThe reaction mixture was filtered
  2. customfollowed by the removal of solvent
  3. customThe crude product was purified by column chromatography (NH, EtOAc)

출처 및 근거

ORD 기록
ord-74dd4d4486cf4557ae5649deffc813e6
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071591B2

반응 노트

불러오는 중…