Acetic Acid → Formylamino-thiophen-2-yl-acetic acid

HRID 655198노트

반응식

HRID 655198 반응식
[NH2:1][CH:2]([C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)[C:3]([OH:5])=[O:4].[C:11](O)(=[O:13])C.O>C(O)=O>[CH:11]([NH:1][CH:2]([C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)[C:3]([OH:5])=[O:4])=[O:13]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 962WaterHCID 894352-Thiopheneacetic acid, alpha-amino-, (-)-

생성물 1

HCID 21492681Formylamino-thiophen-2-yl-acetic acid

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

To a solution of amino-thiophen-2-yl-acetic acid (5 g) in formic acid (50 ml) was added acetic acid (18 ml). After stirring at room temperature for 6 h, water (25 ml) was added. The reaction mixture was stirred for 30 min. The mixture was concentrated in vacuo and triturated with water. The solids were collected by filtration and dried in vacuo (50° C.).

후처리

  1. stirringThe reaction mixture was stirred for 30 min
  2. concentrationThe mixture was concentrated in vacuo
  3. customtriturated with water
  4. filtrationThe solids were collected by filtration
  5. customdried in vacuo (50° C.)

출처 및 근거

ORD 기록
ord-6d2f54b95a5640b48807c99fc7edca73
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071587B2

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