4-Aminophenylacetic acid → (2-Aminobenzothiazol-6-yl)acetic acid
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[NH4+].[N:13]#[C:14][S-:15].BrBr>C(O)(=O)C>[NH2:13][C:14]1[S:15][C:7]2[CH:6]=[C:5]([CH2:8][C:9]([OH:11])=[O:10])[CH:4]=[CH:3][C:2]=2[N:1]=1참가 물질
5
반응 조건
- 온도
- 15 °C
실험 절차
(4-Amino-phenyl)-acetic acid (20 g, 132.5 mmol) and NH4SCN (20 g, 263.2 mmol) were dissolved in 300 ml of acetic acid and the mixture was cooled to 15° C., treated with Br2 (21.2 g, 6.8 ml) in acetic acid (10 ml) and the temperature did not exceed 15° C. Then the reaction was stirred at room temperature for 4 h. The mixture was filtered and the cake was re-dissolved in water, adjusted the pH=5. The precipitate was filtered and dried to obtain 2-amino-benzothiazol-6-yl)-acetic acid as light yellow powder (24 g, 87.1%).
후처리
- customdid not exceed 15° C
- filtrationThe mixture was filtered
- dissolutionthe cake was re-dissolved in water
- filtrationThe precipitate was filtered
- customdried
- customto obtain 2-amino-benzothiazol-6-yl)-acetic acid as light yellow powder (24 g, 87.1%)
출처 및 근거
- ORD 기록
- ord-cedaabdfe45a46bfbb30c10fb27171c5
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08071581B2
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