Methanol → (7-Fluoro-quinolin-6-yl)-acetic acid methyl ester

HRID 655246노트

반응식

HRID 655246 반응식
F[C:2]1[C:11]([CH2:12][C:13]([OH:15])=[O:14])=[C:10]([F:16])[CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.OS(O)(=O)=O.[CH3:22]O>C(OCC)(=O)C>[CH3:22][O:15][C:13](=[O:14])[CH2:12][C:11]1[CH:2]=[C:3]2[C:8](=[CH:9][C:10]=1[F:16])[N:7]=[CH:6][CH:5]=[CH:4]2

참가 물질

5

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 577423352-(5,7-Difluoroquinolin-6-yl)acetic acid

생성물 1

HCID 59320292(7-Fluoro-quinolin-6-yl)-acetic acid methyl ester수율 89.8%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of (5,7-difluoro-quinolin-6-yl)-acetic acid (18.6 g, 83.4 mmol) in methanol (200 mL) was added conc. H2SO4 (4.7 mL, 87.0 mmol). The reaction mixture was concentrated to give a brown residue, which was diluted with 200 ml of ethyl acetate, washed with sat. aq. NaHCO3 and brine, then the organic layer was dried over anhydrous Na2SO4, and concentrated to give (7-fluoro-quinolin-6-yl)-acetic acid methyl ester as yellow solid (17.7 g, yield: 89.8%).

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customto give a brown residue, which
  3. washwashed with sat. aq. NaHCO3 and brine
  4. dry with materialthe organic layer was dried over anhydrous Na2SO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5e75f868a01f4c48831bb8fedb09ace0
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071581B2

반응 노트

불러오는 중…