Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
m-Nitroacetophenone → alpha-Methyl-3-nitrobenzenemethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | m-Nitroacetophenone | HCID 8494 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | alpha-Methyl-3-nitrobenzenemethanol | HCID 223135 | — |
반응 단계
26.4 g (160 mmol) of 1-(3-nitrophenyl)ethanone are suspended in 270 ml of methanol, and 6.1 g (160 mmol) of sodium borohydride are added in portions with ice cooling. The reaction mixture is subsequently stirred for a further 3 h without cooling, diluted with 300 ml of dichloromethane and washed with 3×200 ml of water. The organic phase is dried over sodium sulfate and evaporated to dryness.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08071593B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-68cae19d5e03440abae9b8c78f7b0c6c |
| 출처 메모 | uspto-grants-2011_12 |