3-Ethoxy-2-methylacrylaldehyde → Methyl 3-(5-methylpyrimidin-2-yl)benzoate

HRID 655322

반응식

HRID 655322 반응식
C(O)(=O)C.[C:5]([C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=1)[C:11]([O:13][CH3:14])=[O:12])(=[NH:7])[NH2:6].CCO/[CH:21]=[C:22](/[CH:24]=O)\[CH3:23].C[O-].[Na+]>CO>[CH3:24][C:22]1[CH:21]=[N:7][C:5]([C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=2)[C:11]([O:13][CH3:14])=[O:12])=[N:6][CH:23]=1

참가 물질

5

반응물 3

HCID 30848683-Ethoxy-2-methylacrylaldehydeHCID 10942334Sodium MethoxideHCID 66985510HCID 66985510, 화합물

생성물 1

HCID 59484867Methyl 3-(5-methylpyrimidin-2-yl)benzoate

시약·촉매·용매 1

HCID 887Methanol용매2회

반응 조건

온도
50 °C

실험 절차

2.41 g (10 mmol) of methyl 3-carbamimidoylbenzoate acetate are suspended in 40 ml of methanol, 1.31 ml (11 mmol) of 3-ethoxymethacrolein and 2.04 ml of 30% sodium methoxide in methanol are added, and the mixture is stirred at 50° C. for 15 h. The reaction mixture is evaporated to dryness, and 100 ml of water are added. The precipitate formed is filtered off with suction and dried in vacuo. The crude product is reacted further without further purification; product: 1.65 g; ESI: 229 (M+H).

후처리

  1. customThe reaction mixture is evaporated to dryness, and 100 ml of water
  2. additionare added
  3. customThe precipitate formed
  4. filtrationis filtered off with suction
  5. customdried in vacuo
  6. customThe crude product is reacted further without further purification

출처 및 근거

ORD 기록
ord-339f188cbf48461193f25796b8645b08
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071593B2

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