Dimethylamine → HCID 9400787, 화합물

반응식

Cl[C:2]1[N:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH3:12][NH:13][CH3:14]>>[CH3:12][N:13]([CH3:14])[C:2]1[N:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 674Dimethylamine

HCID 12015126-chloropyridine-3-sulfonamide

생성물 1

HCID 9400787HCID 9400787, 화합물수율 95%

실험 절차

A mixture of 6-chloropyridine-3-sulfonamide (5 g, 0.0259 mol) and aqueous dimethylamine (100 ml, 40%) is stirred at rt for 13 h. The mixture is concentrated to ⅕th of its original volume and cooled. The precipitate is collected by filtration, washed with ice-cold water (10 ml) and dried under vacuum to afford 4.5 g (95%) of the title compound as a solid. mp: 133-138° C., LC/MS: (ES+) 201.9.

후처리

concentrationThe mixture is concentrated to ⅕th of its original volume
temperaturecooled
filtrationThe precipitate is collected by filtration
washwashed with ice-cold water (10 ml)
customdried under vacuum

출처 및 근거

ORD 기록: ord-c6187a94f133448eb1d446df590dd669
출처 데이터셋: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08071597B2

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