Methyl (3S,4R)-4-(benzylamino)-3-methylpiperidine-1-carboxylate → Methyl (3S,4R)-4-amino-3-methylpiperidine-1-carboxylate

HRID 655770노트

반응식

HRID 655770 반응식
C([NH:8][C@@H:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][C@@H:10]1[CH3:19])C1C=CC=CC=1>CO.[H][H].[Pd]>[NH2:8][C@@H:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][C@@H:10]1[CH3:19]

참가 물질

5

반응물 1

HCID 58075022Methyl (3S,4R)-4-(benzylamino)-3-methylpiperidine-1-carboxylate

생성물 1

HCID 58075083Methyl (3S,4R)-4-amino-3-methylpiperidine-1-carboxylate수율 101.6%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 178418361HCID 178418361, 화합물용매

실험 절차

Methyl (3S,4R)-4-(benzylamino)-3-methylpiperidine-1-carboxylate (8.0 g, 0.02 mol) was dissolved in methanol (200 mL) and hydrogenated at room temperature, under 50 psi of hydrogen pressure, in the presence of palladium (2.5 g) on carbon for 2 h. The solution was then filtered and concentrated under reduced pressure to yield 3.5 g (92%) Methyl (3S,4R)-4-amino-3-methylpiperidine-1-carboxylate as liquid.

후처리

  1. filtrationThe solution was then filtered
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e25b30d485d84329aefc171162f2844d
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071605B2

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