참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | O,O-diethyl phosphorochloridothioate | HCID 17305 | — |
| 반응물 | 5-(Ethylsulfanyl)-3-hydroxythiophene-2-carbonitrile | HCID 21317930 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-Cyano-3-(diethoxythiophosphoryloxy)-5-ethylthio-thiophene | HCID 53827054 | 86.8% |
반응 단계
7 g of potassium carbonate and 9.4 g of O,O-diethyl chlorothiophosphate were added to a solution of 9.3 g of 2-cyano-3-hydroxy-5-ethylthio-thiophene in 150 ml of acetonitrile and the mixture was stirred for 24 hours at 20° C. and was filtered. The filtrate was evaporated to dryness and the residue was chromatographed over silica gel. Elution with an 8-2 cyclohexane-ethyl acetate mixture yielded 14.6 g of 2-cyano-3-(diethoxythiophosphoryloxy)-5-ethylthio-thiophene with a refractive index of nD20 = 1.5635.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04128562 |
|---|
| 출처 데이터셋 | uspto-grants-1978_12 |
|---|
| ORD ID | ord-e62d9c3939ae42bf9f760fd70880f123 |
|---|
| 출처 메모 | uspto-grants-1978_12 |
|---|
