Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,4,7-Triazacyclononane → Ethyl 6-((4,7-bis((6-(ethoxycarbonyl)-4-(2,4,6-trimethoxyphenyl)-pyridin-2-yl)methyl)-1,4,7-triazonan-1-yl)methyl)-4-(2,4,6-trimethoxyphenyl)-pyridine-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,4,7-Triazacyclononane | HCID 188318 | — |
| 반응물 | 4-(2,4,6-trimethoxyphenyl)-6-(bromomethyl)pyridine-2-carboxylic Acid Ethyl Ester | HCID 59024661 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Ethyl 6-((4,7-bis((6-(ethoxycarbonyl)-4-(2,4,6-trimethoxyphenyl)-pyridin-2-yl)methyl)-1,4,7-triazonan-1-yl)methyl)-4-(2,4,6-trimethoxyphenyl)-pyridine-2-carboxylate | HCID 11194088 | 62.4% |
반응 단계
1,4,7-triazacyclononane (31.5 mg) and compound 14 (0.3 g, 0.76 mmol) were dissolved in dry acetonitrile (20 mL) Potassium carbonate (0.17 g) was added and the mixture was refluxed overnight. The mixture was allowed to cool to room temperature, filtered and concentrated. Purification on silica gel (eluent CH2Cl2:EtOH: HOAc; 80:20:1, v/v/v) yielded the title compound (0.17 g, 62%). ESI-MS: [M+H]+ 1117.5 calc. for C60H73N6O15+1117.5.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08071626B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-77d543bce43c4d27b8ae8d04b40bc3b2 |
| 출처 메모 | uspto-grants-2011_12 |