Trifluoroacetic acid → 2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-1-butanamine hydrochloride

HRID 655921노트

반응식

HRID 655921 반응식
[Cl:1][C:2]1[C:3]([CH:12]([CH2:22][CH3:23])[CH2:13][NH:14]C(=O)OC(C)(C)C)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.FC(F)(F)C(O)=O>ClCCl>[ClH:1].[Cl:1][C:2]1[C:3]([CH:12]([CH2:22][CH3:23])[CH2:13][NH2:14])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 23078240Tert-butyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]butylcarbamate

생성물 1

HCID 667981942-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-1-butanamine hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

146 g of tert-butyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]butylcarbamate (0.414 mol) are dissolved in 2 L of dichloromethane. 190 mL of trifluoroacetic acid are added dropwise. The reaction mixture is stirred at room temperature for twelve hours, concentrated to dryness and diluted in 300 mL of hydrochloric acid 2M.

후처리

  1. concentrationconcentrated to dryness
  2. additiondiluted in 300 mL of hydrochloric acid 2M

출처 및 근거

ORD 기록
ord-f0997891f17c4e0d81f70f76dd423c90
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071627B2

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