L-Prolinol → (S)-N-(2-chlorobenzyl)-2-(hydroxymethyl)pyrrolidine-1-carboxamide

HRID 655961

반응식

HRID 655961 반응식
[NH:1]1[CH2:5][CH2:4][CH2:3][C@H:2]1[CH2:6][OH:7].[Cl:8][C:9]1[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=1[CH2:11][N:12]=[C:13]=[O:14]>C1COCC1>[Cl:8][C:9]1[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=1[CH2:11][NH:12][C:13]([N:1]1[CH2:5][CH2:4][CH2:3][C@H:2]1[CH2:6][OH:7])=[O:14]

참가 물질

4

반응물 2

HCID 640091L-ProlinolHCID 27333671-Chloro-2-(isocyanatomethyl)benzene

생성물 1

HCID 59778476(S)-N-(2-chlorobenzyl)-2-(hydroxymethyl)pyrrolidine-1-carboxamide수율 103.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of (S)-pyrrolidin-2-ylmethanol (110 mg, 1.1 mmol) in THF (2.0 mL) was added 2-chlorobenzyl-isocyanate (167 mg, 1.0 mmol). The reaction mixture was stirred for 1 h and concentrated under reduced pressure to give (S)—N-(2-chlorobenzyl)-2-(hydroxymethyl)pyrrolidine-1-carboxamide as an oil (277 mg), which was used without further purification. LRMS (M+H+) m/z 269.0.

후처리

  1. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a991fe07ec824809a33d3c3ebc1dbca3
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071625B2

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