Methyl 5-bromoindoline-7-carboxylate → methyl 5-bromo-1H-indole-7-carboxylate
반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:10]=1)[NH:7][CH2:6][CH2:5]2>O1CCCC1.[O-2].[O-2].[Mn+4]>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:10]=1)[NH:7][CH:6]=[CH:5]2참가 물질
4
실험 절차
Methyl 5-bromo-2,3-dihydro-1H-indole-7-carboxylate (6.5 g, 25 mmol) was dissolved in tetrahydrofuran (100 mL). Activated manganese dioxide (5 μm particle size, 22 g, 250 mmol) was added and the mixture stirred at room temperature for 16 hours. A further 22 g of activated manganese dioxide was added and the reaction stirred for 96 hours. The reaction was then filtered through celite and concentrated in vacuo to give 5.1 g (80%) of the title compound as a beige solid.
후처리
- stirringthe reaction stirred for 96 hours
- filtrationThe reaction was then filtered through celite and
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-92feb91ec1944631b25b642e80d6f1d2
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08071584B2
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