Methylamine → HCID 66707598, 화합물

HRID 656222노트

반응식

HRID 656222 반응식
[CH3:1][NH2:2].C[O:4][C:5](=O)[CH2:6][CH2:7][CH:8]1[CH2:13][CH2:12][CH:11]=[CH:10][CH2:9]1>CO>[CH:8]1([CH2:7][CH2:6][C:5]([NH:2][CH3:1])=[O:4])[CH2:13][CH2:12][CH:11]=[CH:10][CH2:9]1

참가 물질

4

반응물 2

HCID 6329Methylamine2회HCID 12772855Methyl 3-(cyclohex-3-en-1-yl)propanoate

생성물 1

HCID 66707598HCID 66707598, 화합물수율 98%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl amine (8 M in EtOH, 75 ml, 600 mmol) was added to a mixture of 3-cyclohex-3-enyl-propionic acid methyl ester (German patent DE 4023848 A1 19920130) (20.0 g, 119 mmol) in 75 mL of methanol. The mixture was stirred at room temperature for one day. Additional Methyl amine (8 M in EtOH, 40 ml, 320 mmol) was added to the mixture and stirring continued for one more day. The mixture was concentrated and the residue was taken up in ethyl acetate, washed with 0.5 M aqueous HCl, dried and stripped of the solvent to give the title compound (19.50 g, 98% yield, uncorrected) as a pale orange solid.

후처리

  1. stirringstirring
  2. concentrationThe mixture was concentrated
  3. washwashed with 0.5 M aqueous HCl
  4. customdried

출처 및 근거

ORD 기록
ord-f8a95b11120a458fa867e3bbf86e5931
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071643B2

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