6-Methoxy-2-hexanone → HCID 86639839, 화합물

HRID 656239노트

반응식

HRID 656239 반응식
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7](=[O:9])[CH3:8].[Cl-:10].[Li+]>CN(C)C=O.O.[Cu](Cl)Cl>[Cl:10][CH:6]([CH2:5][CH2:4][CH2:3][O:2][CH3:1])[C:7](=[O:9])[CH3:8]

참가 물질

5

반응물 2

HCID 344156-Methoxy-2-hexanoneHCID 433294Lithium Chloride

생성물 1

HCID 86639839HCID 86639839, 화합물

시약·촉매·용매 2

HCID 16219111Copper(II) chloride dihydrate촉매HCID 6228Dimethylformamide용매2회

반응 조건

온도
85 °C

실험 절차

1.5 mol of 6-methoxyhexan-2-one [29006-00-6] are added to a mixture of 3.6 mol of copper(II) chloride hydrate and 1.8 mol of lithium chloride in 900 ml of N,N-dimethylformamide at 80° C. The reaction mixture is stirred at 80-90° C. for 1 hour. 900 g of ice are added, and the precipitate is dissolved by adding N,N-dimethylformamide. Extraction with pentane (6×) is carried out. The combined organic phases are washed with water, dried over sodium sulphate and fractionated in vacuo. The title compound is identified by means of the Rf.

후처리

  1. dissolutionthe precipitate is dissolved
  2. extractionExtraction with pentane (6×)
  3. washThe combined organic phases are washed with water
  4. dry with materialdried over sodium sulphate

출처 및 근거

ORD 기록
ord-74c7c43ec2a34bb98c762563df4e4925
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071651B2

반응 노트

불러오는 중…