2-(Methylsulfonamido)phenylacetonitrile → N-[2-(2-aminoethyl)phenyl]methanesulfonamide

HRID 656271노트

반응식

HRID 656271 반응식
[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][C:13]#[N:14])(=[O:4])=[O:3]>CO.[Pd]>[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][CH2:13][NH2:14])(=[O:4])=[O:3]

참가 물질

4

반응물 1

HCID 691184052-(Methylsulfonamido)phenylacetonitrile

생성물 1

HCID 20848391N-[2-(2-aminoethyl)phenyl]methanesulfonamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

(2-Methanesulfonylaminophenyl)acetonitrile (300 mg) was mixed with 10% palladium/carbon (catalytic amount) in methanol (20 ml) and the mixture was stirred under hydrogen gas atmospheres for 48 hours. After confirming the completion of the reaction using TLC, the resulting mixture was filtered through celite and the filtrate was concentrated under reduced pressure. The following procedure was carried out using the concentrate which was not purified.

후처리

  1. filtrationthe resulting mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. concentrationconcentrate which
  4. customwas not purified

출처 및 근거

ORD 기록
ord-234744b45fc34bb790657b2e28e616eb
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071650B2

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