Furfurylamine → 1-(Furan-2-ylmethyl)-3-(4-methoxybenzyl)thiourea

HRID 656283노트

반응식

HRID 656283 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH2:7].C(N(CC)CC)C.[CH3:15][O:16][C:17]1[CH:26]=[CH:25][C:20]([CH2:21][N:22]=[C:23]=[S:24])=[CH:19][CH:18]=1>CN(C)C=O.C(OCC)(=O)C>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:7][C:23]([NH:22][CH2:21][C:20]1[CH:25]=[CH:26][C:17]([O:16][CH3:15])=[CH:18][CH:19]=1)=[S:24]

참가 물질

6

반응물 3

HCID 3438FurfurylamineHCID 8471TriethylamineHCID 1231974-Methoxybenzyl isothiocyanate

생성물 1

HCID 9781801-(Furan-2-ylmethyl)-3-(4-methoxybenzyl)thiourea수율 92.5%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

Furan-2-ylmethylamine (190 mg) was dissolved in dimethylformamide (5 ml) and to the solution were added triethylamine (200 mg) and 4-methoxybenzylisothiocyanate (360 mg), followed by stirring at room temperature for 24 hours. Then, the resulting mixture was diluted with ethyl acetate, washed with water, dried, and concentrated under reduced pressure. The residue was purified by column-chromatography (hexane/ethyl acetate=1/1) to yield the compound 16-1 (0.5 g, 90%) as a liquid.

후처리

  1. washwashed with water
  2. customdried
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified by column-chromatography (hexane/ethyl acetate=1/1)

출처 및 근거

ORD 기록
ord-4aed6ed970074ad2abed7d319ea0de3c
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071650B2

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