Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(1-methyl-1H-pyrrol-2-yl)methanamine → 1-(4-t-butylbenzyl)-3-(1-methyl-1H-pyrrol-2-yl)methylthiourea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (1-methyl-1H-pyrrol-2-yl)methanamine | HCID 2776207 | — |
| 반응물 | 1-Tert-butyl-4-(isothiocyanatomethyl)benzene | HCID 14801041 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-(4-t-butylbenzyl)-3-(1-methyl-1H-pyrrol-2-yl)methylthiourea | HCID 59088065 | 75.9% |
반응 단계
(1-methyl-1H-pyrrol-2-yl)methylamine (65 mg) and 4-t-butylbenzylisothiocyanate (120 mg) were dissolved in ethyl acetate (30 ml) and the solution was stirred for 12 hours. After the completion of the reaction, the resulting mixture was purified by column-chromatography (ethyl acetate/hexane=1/3) to yield the compound 17-2 (140 mg, 75%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08071650B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-ad0f65674d824e39a75806ea578f636e |
| 출처 메모 | uspto-grants-2011_12 |