5-Chloro-7-nitro-2,3-dihydro-1,3-benzoxazol-2-one → 7-Amino-2(3H)-benzoxazolone

HRID 656378노트

반응식

HRID 656378 반응식
Cl[C:2]1[CH:3]=[C:4]([N+:12]([O-])=O)[C:5]2[O:9][C:8](=[O:10])[NH:7][C:6]=2[CH:11]=1>CCO.[Pd]>[NH2:12][C:4]1[C:5]2[O:9][C:8](=[O:10])[NH:7][C:6]=2[CH:11]=[CH:2][CH:3]=1

참가 물질

4

반응물 1

HCID 299761115-Chloro-7-nitro-2,3-dihydro-1,3-benzoxazol-2-one

생성물 1

HCID 111478147-Amino-2(3H)-benzoxazolone

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of 5-chloro-7-nitro-1,3-benzoxazol-2(3H)-one from Step A (1.10 g, 5.13 mmol) in EtOH (50 mL) was added 10% Pd/C (300 mg). The reaction mixture was shaken in a Parr aparatus under a hydrogen atmosphere (40 p.s.i.) for 18 h, then filtered through a Celite pad, washing with EtOH, and the filtrate was concentrated under reduced pressure to give the title compound. MS: m/z=151 (M+1).

후처리

  1. filtrationfiltered through a Celite pad
  2. washwashing with EtOH
  3. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a28a9125f1e14bdd92cf528505611527
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071770B2

반응 노트

불러오는 중…