Toluene → 5,7-dimethyl-2-oxo-3(2H)-Benzoxazoleacetic acid
반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH3:20])[C:5]2[O:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])[C:6]=2[CH:19]=1.C1(C)C=CC=CC=1>C(Cl)Cl.C(C(O)=O)(F)(F)F>[CH3:1][C:2]1[CH:3]=[C:4]([CH3:20])[C:5]2[O:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([OH:14])=[O:13])[C:6]=2[CH:19]=1참가 물질
5
실험 절차
A solution of the tert-butyl (5,7-dimethyl-2-oxo-1,3-benzoxazol-3(2H)-yl)acetate from Step A in CH2Cl2 (0.7 mL) and CF3CO2H (0.3 mL) was stood at ambient temperature for 2 h. Toluene (5 mL) was added and the mixture was concentrated in vacuo to give the title compound as a dark solid. MS: m/z=222 (M+1).
후처리
- concentrationthe mixture was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-8f9a1b82217847c48fb2e9aee059a9ca
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08071771B2
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