Dimethyldioxirane → 2-Oxo-3-(2-oxo-3-pyridin-2-yl-2,3-dihydro-1H-benzimidazol-1-yl)propanal

HRID 656419노트

반응식

HRID 656419 반응식
N=[CH:2][C:3](=[O:21])[CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[C:6]1=[O:20].CC1(C)O[O:24]1>CC(C)=O>[O:21]=[C:3]([CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[C:6]1=[O:20])[CH:2]=[O:24]

참가 물질

4

반응물 2

HCID 115197DimethyldioxiraneHCID 866322931-(3-Imino-2-oxopropyl)-3-pyridin-2-yl-1,3-dihydro-2H-benzimidazol-2-one

생성물 1

HCID 574361812-Oxo-3-(2-oxo-3-pyridin-2-yl-2,3-dihydro-1H-benzimidazol-1-yl)propanal

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a stirred solution of 1-(3-imino-2-oxopropyl)-3-pyridin-2-yl-1,3-dihydro-2H-benzimidazol-2-one from Step A (54 mg, 0.19 mmol) in acetone (2 mL) at 0° C. was added a solution of dimethyldioxirane (0.02 M in acetone, 9.6 mL, 0.19 mmol). The reaction mixture was stirred for 90 min then concentrated in vacuo to give the title compound in sufficient purity for use in the next step.

후처리

  1. concentrationthen concentrated in vacuo

출처 및 근거

ORD 기록
ord-1ffb6a63911c4ee8aa1813e7260f42c5
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071771B2

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