Piperidine → 5-(Piperidin-1-yl)-2,3-dihydro-1H-inden-1-one
반응식
F[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[CH2:6][CH2:5]2.[NH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>N1C=CC=CC=1>[N:12]1([C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[C:7](=[O:11])[CH2:6][CH2:5]3)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1참가 물질
4
실험 절차
5-Fluoroindan-1-one (5 g, 33.3 mmol) and piperidine (8.52 g, 100 mmol, 10 ml) were dissolved in pyridine (20 ml) and heated to reflux for 3 hours. The reaction mixture was cooled, the solvent removed under vacuum, and the residue taken in diethyl ether. The ether solution was washed with 1N aqueous sodium hydroxide and with water, dried with magnesium sulfate, filtered, and the filtrate was removed under vacuum to provide the title compound which was used without further purification.
후처리
- temperatureheated
- temperatureto reflux for 3 hours
- temperatureThe reaction mixture was cooled
- customthe solvent removed under vacuum
- washThe ether solution was washed with 1N aqueous sodium hydroxide and with water
- dry with materialdried with magnesium sulfate
- filtrationfiltered
- customthe filtrate was removed under vacuum
출처 및 근거
- ORD 기록
- ord-e725bb48ddc94ee48416fbed064d7f43
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08071762B2
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