8-Azidomethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol → 8-Aminomethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol
반응식
[N:1]([CH2:4][C:5]1([OH:14])[CH2:10][CH2:9][CH2:8][N:7]2[CH:11]=[N:12][CH:13]=[C:6]12)=[N+]=[N-].[H][H]>CO.[Pd]>[NH2:1][CH2:4][C:5]1([OH:14])[CH2:10][CH2:9][CH2:8][N:7]2[CH:11]=[N:12][CH:13]=[C:6]12참가 물질
5
실험 절차
3 mmol of 8-azidomethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol are taken up in 10 ml of methanol and the solution is admixed with 0.30 mmol of 10% Pd/C. The reaction mixture is hydrogenated with a hydrogen pressure of 1 bar at 22° C. for 1-10 hours. The catalyst is filtered off over Hyflo and the filtrate is evaporated. From the residue the title compound is identified by means of flash chromatography (SiO2 60 F) on the basis of the Rf value.
후처리
- filtrationThe catalyst is filtered off over Hyflo
- customthe filtrate is evaporated
출처 및 근거
- ORD 기록
- ord-c224be4d5dbc49dc838dc34ab96079b0
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08071773B2
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