Water → 8-Azidomethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol
반응식
[O:1]1[CH2:3][C:2]21[CH2:8][CH2:7][CH2:6][N:5]1[CH:9]=[N:10][CH:11]=[C:4]21.[N-:12]=[N+:13]=[N-:14].[Na+].O>CN(C)C=O>[N:12]([CH2:3][C:2]1([OH:1])[CH2:8][CH2:7][CH2:6][N:5]2[CH:9]=[N:10][CH:11]=[C:4]12)=[N+:13]=[N-:14]참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
A solution of 5 mmol of 6,7-dihydro-5H-spiro[imidazo[1,5-a]pyridine-8,2′-oxirane] in 15 ml of N,N-dimethylformamide is admixed with 10 mmol of sodium azide and the reaction mixture is heated at 60° C. for 4 hours. The mixture is poured into water and extracted with tert-butyl methyl ether. The combined organic extracts are washed with brine, dried with sodium sulphate and evaporated. From the residue the title compound is identified by means of flash chromatography (SiO2 60 F) on the basis of the Rf value.
후처리
- extractionextracted with tert-butyl methyl ether
- washThe combined organic extracts are washed with brine
- dry with materialdried with sodium sulphate
- customevaporated
출처 및 근거
- ORD 기록
- ord-ccc038570b394a97a4903bdc27837725
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08071773B2
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