2-(2-Amino-5-bromophenyl)acetonitrile → 4-Amino-3-cyanomethyl-benzonitrile

HRID 656504노트

반응식

HRID 656504 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5](Br)=[CH:4][C:3]=1[CH2:9][C:10]#[N:11].[Cu][C:13]#[N:14]>CN1CCCC1=O.O>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:13]#[N:14])=[CH:4][C:3]=1[CH2:9][C:10]#[N:11]

참가 물질

5

반응물 2

HCID 450370522-(2-Amino-5-bromophenyl)acetonitrileHCID 178418546HCID 178418546, 화합물

생성물 1

HCID 574685124-Amino-3-cyanomethyl-benzonitrile

시약·촉매·용매 2

HCID 962Water용매HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

2 mmol of (2-Amino-5-bromo-phenyl)-acetonitrile [882855-95-0] and 4 mmol of copper (I) cyanide are heated at 200° C. in 2 ml of N-methylpyrrolidinone for 4 h. After cooling to room temperature, the solution is diluted with water and extracted with ethyl acetate (3×). The organic layer is separated, dried over magnesium sulphate and evaporated. From the residue the title compound is identified by means of flash chromatography (SiO2 60F) on the basis of the Rf value.

후처리

  1. extractionextracted with ethyl acetate (3×)
  2. customThe organic layer is separated
  3. dry with materialdried over magnesium sulphate
  4. customevaporated

출처 및 근거

ORD 기록
ord-f3c9c2b3802e4bf897b90a1d94cf78ed
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071774B2

반응 노트

불러오는 중…