1,8-Diazabicyclo(5.4.0)undec-7-ene → 1-(2-Cyclopropylethenyl)-2-nitrobenzene
반응식
Cl[CH:2]([CH:13]1[CH2:15][CH2:14]1)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N+:10]([O-:12])=[O:11].N12CCCN=C1CCCCC2>O1CCOCC1>[CH:13]1([CH:2]=[CH:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[N+:10]([O-:12])=[O:11])[CH2:15][CH2:14]1참가 물질
4
실험 절차
To 1 g (4.25 mmol, purity 96%) of 1-(2-chloro-2-cyclopropylethyl)-2-nitrobenzene in 20 ml of dioxane is added 0.65 g (4.25 mmol) of 1,8-diazabicyclo(5.4.0)undec-7-ene, and the mixture is stirred at room temperature for 12 h. Subsequently, the solvent is concentrated under reduced pressure and the residue is admixed with ethyl acetate and water. After the organic phases have been removed and the solvent has been concentrated by evaporation, 0.7 g (79% of theory) of 1-[2-cyclopropylvinyl]-2-nitrobenzene is obtained.
후처리
- concentrationSubsequently, the solvent is concentrated under reduced pressure
- customAfter the organic phases have been removed
- concentrationthe solvent has been concentrated by evaporation
출처 및 근거
- ORD 기록
- ord-5b668dae0c99493ebe7849fde34182b6
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08071824B2
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