Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 3-Hydroxy-2-phenethyl-5,6-dimethoxy-2,3-dihydro-1H-isoindol-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | Potassium borohydride | HCID 4192641 | — |
| 반응물 | 5,6-Dimethoxy-2-(2-phenylethyl)-1H-isoindole-1,3(2H)-dione | HCID 22757553 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-Hydroxy-2-phenethyl-5,6-dimethoxy-2,3-dihydro-1H-isoindol-1-one | HCID 22757554 | 96.9% |
반응 단계
Potassium borohydride (4.87 g) dissolved in distilled water (58.7 cc) is added to 4,5-dimethoxy-N-phenethyl phthalimide (28 g) suspended in a mixture (180 cc) consisting of equal volumes of dioxan and methanol. The reaction mixture is heated under reflux for 2 hours and then concentrated to a volume of 60 cc and distilled water (450 cc) is added. After cooling, the resulting precipitate is filtered off, washed three times with distilled water (total 1000 cc) and dried under reduced pressure (20 mm Hg) at 25° C. 3-Hydroxy-2-phenethyl-5,6-dimethoxy-2,3-dihydro-1H-isoindol-1-one (27.3 g), melting at 130° C., is thus obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04128650 |
| 출처 데이터셋 | uspto-grants-1978_12 |
| ORD ID | ord-8df3739a1b454da3873c39b824b653b5 |
| 출처 메모 | uspto-grants-1978_12 |