Sodium Bicarbonate → Methyl 6-(methyloxy)-1,5-naphthyridine-3-carboxylate

HRID 656919노트

반응식

HRID 656919 반응식
Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[N:10]=2)[N:5]=[CH:4][C:3]=1[C:14]([O:16][CH3:17])=[O:15].C([O-])(O)=O.[Na+].[H][H]>CO.O1CCOCC1.[Pd]>[CH3:13][O:12][C:9]1[N:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][C:3]([C:14]([O:16][CH3:17])=[O:15])=[CH:2]2

참가 물질

7

반응물 3

HCID 516892Sodium BicarbonateHCID 68817384Methyl 4-bromo-6-(methyloxy)-1,5-naphthyridine-3-carboxylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 68817307Methyl 6-(methyloxy)-1,5-naphthyridine-3-carboxylate수율 96.7%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

To a mixture of methyl 4-bromo-6-(methyloxy)-1,5-naphthyridine-3-carboxylate (1.67 g, 5.64 mmol)) and NaHCO3 (0.84 g, 10 mmol) in MeOH (20 ml) and 1,4-dioxane (15 ml) was added 10% Pd/C (0.75 g) and the mixture was then stirred at rt under 1 atmosphere of hydrogen for 3 h. The reaction mixture was then filtered through a thin pad of Celite, washing through with EtOH. The filtrate was evaporated and stirred in 50 ml of water, the solid was then filtered off and dried in vacuo to give the desired product (1.19 g, 96%).

후처리

  1. filtrationThe reaction mixture was then filtered through a thin pad of Celite
  2. washwashing through with EtOH
  3. customThe filtrate was evaporated
  4. filtrationthe solid was then filtered off
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-c7c3825cc9c54cba81d449bf891bfbbb
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071592B2

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