Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl 2-[4-(tert-butoxycarbonylamino)piperidin-1-yl]ethylcarbamate → 1,1-Dimethylethyl N-[1-(2-aminoethyl)-4-piperidinyl]carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl 2-[4-(tert-butoxycarbonylamino)piperidin-1-yl]ethylcarbamate | HCID 22989976 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1,1-Dimethylethyl N-[1-(2-aminoethyl)-4-piperidinyl]carbamate | HCID 23562647 | 101.8% |
반응 단계
A solution of 1,1-dimethylethyl {1-[2-({[(phenylmethyl)oxy]carbonyl}amino)ethyl]-4-piperidinyl}carbamate (8.2 g, 21.8 mmol) in ethanol (500 ml) was hydrogenated overnight over 10% palladium on charcoal (50% dispersion with water, 4.0 g). The mixture was filtered, evaporated, and azeotroped with chloroform to afford the title intermediate (5.4 g, 100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08071592B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-7c39fd70e4614128b5e93581d7484dd1 |
| 출처 메모 | uspto-grants-2011_12 |