2,3-Dihydrofuro[2,3-c]pyridin-5-ylmethanol → 2,3-Dihydrofuro[2,3-c]pyridine-5-carbaldehyde

HRID 656969노트

반응식

HRID 656969 반응식
[O:1]1[C:5]2=[CH:6][N:7]=[C:8]([CH2:10][OH:11])[CH:9]=[C:4]2[CH2:3][CH2:2]1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[O:1]1[C:5]2=[CH:6][N:7]=[C:8]([CH:10]=[O:11])[CH:9]=[C:4]2[CH2:3][CH2:2]1

참가 물질

4

반응물 1

HCID 574231212,3-Dihydrofuro[2,3-c]pyridin-5-ylmethanol

생성물 1

HCID 574231162,3-Dihydrofuro[2,3-c]pyridine-5-carbaldehyde수율 70%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

2,3-Dihydrofuro[2,3-c]pyridin-5-ylmethanol (1.31 g, 8.7 mmol) was dissolved in DCM (100 ml), treated with manganese (IV) dioxide (6 g, 69 mmol) and heated under reflux for 18 h. Filtration through kieselguhr and evaporation of the filtrate to dryness gave an oil (0.9 g, 70%).

후처리

  1. temperatureheated
  2. temperatureunder reflux for 18 h
  3. filtrationFiltration
  4. customthrough kieselguhr and evaporation of the filtrate to dryness

출처 및 근거

ORD 기록
ord-204f64b952994cb287df8dd77a7e986a
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071592B2

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